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These diagnostic applications can be used, for example, to assess cardiac physiology, respiratory physiology, muscle strength, and muscle endurance (Duren et al., 2008

Cheng S-J, Chiu H-Y, Kumar PV, Hsieh KY, Yang J-W, Lin Y-R, et al

Moreover, ALS is often further characterized by dysregulated proteostasis and autophagy, which can cause an excess of unfolded proteins, including stress granules, and TDP-43 pathologies